Uncoupling the roles of firing rates and spike bursts in shaping the STN-GPe beta band oscillations.

ABSTRACT: The excess of 15-30 Hz (β-band) oscillations in the basal ganglia is one of the key signatures of Parkinson's disease (PD). The STN-GPe network is integral to generation and modulation of β band oscillations in basal ganglia. However, the role of changes in the firing rates and spike bursting of STN and GPe neurons in shaping these oscillations has remained unclear. In order to uncouple their effects, we studied the dynamics of STN-GPe network using numerical simulations. In particular, we used a neuron model, in which firing rates and spike bursting can be independently controlled. Using this model, we found that while STN firing rate is predictive of oscillations, GPe firing rate is not. The effect of spike bursting in STN and GPe neurons was state-dependent. That is, only when the netwo

SUBMITTER: Bahuguna J 

PROVIDER: S-EPMC7145269 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature