Long-Term Patterns of Oral Anticancer Agent Adoption, Duration, and Switching in Patients With CML.

ABSTRACT:

Background

Oral tyrosine kinase inhibitors (TKIs) have been the standard of care for chronic myeloid leukemia (CML) since 2001. However, few studies have evaluated changes in the treatment landscape of CML over time. This study assessed the long-term treatment patterns of oral anticancer therapies among patients with CML.

Methods

This retrospective cohort study included patients newly diagnosed with CML between January 1, 2000, and December 31, 2016, from 10 integrated healthcare systems. The proportion of patients treated with 5 FDA-approved oral TKI agents-bosutinib, dasatinib, imatinib, nilotinib, and ponatinib-in the 12 months after diagnosis were measured, overall and by year, between 2000 and 2017. We assessed the use of each oral agent through the fourth-line setting.

SUBMITTER: Banegas MP 

PROVIDER: S-EPMC7145440 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature