Limited replicability of drug-induced amnesia after contextual fear memory retrieval in rats.

ABSTRACT: With the ultimate goal of investigating boundary conditions for post-reactivation amnesia, we set out to replicate studies in which systemic, post-reactivation administration of midazolam, propranolol, or cycloheximide resulted in amnesia for contextual fear memories. Our experiments involved conceptual as well as exact replications of previously published studies. In most of our experiments, we adopted a procedure that conformed to the standard 3-day protocol typically used in the literature, with contextual fear conditioning on day 1, unreinforced re-exposure to the conditioning context followed by systemic injection of the amnestic drug on day 2, and a memory retention test on day 3. Given the plethora of successful studies with large effects sizes and the absence of any failed replicat

SUBMITTER: Schroyens N 

PROVIDER: S-EPMC7145453 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature