Behavioral Pharmacology of Novel Kappa Opioid Receptor Antagonists in Rats.

ABSTRACT:

Background

New treatments for stress-related disorders including depression, anxiety, and substance use disorder are greatly needed. Kappa opioid receptors are expressed in the central nervous system, including areas implicated in analgesia and affective state. Although kappa opioid receptor agonists share the antinociceptive effects of mu opioid receptor agonists, they also tend to produce negative affective states. In contrast, selective kappa opioid receptor antagonists have antidepressant- and anxiolytic-like effects, stimulating interest in their therapeutic potential. The prototypical kappa opioid receptor antagonists (e.g., norBNI, JDTic) have an exceptionally long duration of action that complicates their use in humans, particularly in tests to establish safety. This study

SUBMITTER: Page S 

PROVIDER: S-EPMC7145521 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature