Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics.

ABSTRACT: Knowledge of therapeutic targets and early drug candidates is useful for improved drug discovery. In particular, information about target regulators and the patented therapeutic agents facilitates research regarding druggability, systems pharmacology, new trends, molecular landscapes, and the development of drug discovery tools. To complement other databases, we constructed the Therapeutic Target Database (TTD) with expanded information about (i) target-regulating microRNAs and transcription factors, (ii) target-interacting proteins, and (iii) patented agents and their targets (structures and experimental activity values if available), which can be conveniently retrieved and is further enriched with regulatory mechanisms or biochemical classes. We also updated the TTD with the recently rel

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7145558 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature