MRI radiomic features are associated with survival in melanoma brain metastases treated with immune checkpoint inhibitors.

ABSTRACT:

Background

Melanoma brain metastases historically portend a dismal prognosis, but recent advances in immune checkpoint inhibitors (ICIs) have been associated with durable responses in some patients. There are no validated imaging biomarkers associated with outcomes in patients with melanoma brain metastases receiving ICIs. We hypothesized that radiomic analysis of magnetic resonance images (MRIs) could identify higher-order features associated with survival.

Methods

Between 2010 and 2019, we retrospectively reviewed patients with melanoma brain metastases who received ICI. After volumes of interest were drawn, several texture and edge descriptors, including first-order, Haralick, Gabor, Sobel, and Laplacian of Gaussian (LoG) features were extracted. Progression was determine

SUBMITTER: Bhatia A 

PROVIDER: S-EPMC7145582 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature