PathDIP 4: an extended pathway annotations and enrichment analysis resource for human, model organisms and domesticated species.

ABSTRACT: PathDIP was introduced to increase proteome coverage of literature-curated human pathway databases. PathDIP 4 now integrates 24 major databases. To further reduce the number of proteins with no curated pathway annotation, pathDIP integrates pathways with physical protein-protein interactions (PPIs) to predict significant physical associations between proteins and curated pathways. For human, it provides pathway annotations for 5366 pathway orphans. Integrated pathway annotation now includes six model organisms and ten domesticated animals. A total of 6401 core and ortholog pathways have been curated from the literature or by annotating orthologs of human proteins in the literature-curated pathways. Extended pathways are the result of combining these pathways with protein-pathway associatio

SUBMITTER: Rahmati S 

PROVIDER: S-EPMC7145646 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature