Retinal Changes in Schizophrenia: A Systematic Review and Meta-analysis Based on Individual Participant Data.

ABSTRACT:

Background

Retinal assessment has indicated the presence of neuronal loss in neurodegenerative disorders, but its role in schizophrenia remains unclear. We sought to synthesize the available evidence considering 3 noninvasive modalities: optical coherence tomography, electroretinography, and fundus photography, and examine their diagnostic accuracy based on unpublished individual participant data, when provided by the primary study authors.

Methods

We searched MEDLINE, SCOPUS, clinicaltrials.gov, PSYNDEX, Cochrane Controlled Register of Trials (CENTRAL), WHO International Clinical Trials Registry Platform, and Google Scholar, up to October 30, 2018. Authors were contacted and invited to share anonymized participant-level data. Aggregate data were pooled using random effects

SUBMITTER: Kazakos CT 

PROVIDER: S-EPMC7145676 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature