ENdb: a manually curated database of experimentally supported enhancers for human and mouse.

ABSTRACT: Enhancers are a class of cis-regulatory elements that can increase gene transcription by forming loops in intergenic regions, introns and exons. Enhancers, as well as their associated target genes, and transcription factors (TFs) that bind to them, are highly associated with human disease and biological processes. Although some enhancer databases have been published, most only focus on enhancers identified by high-throughput experimental techniques. Therefore, it is highly desirable to construct a comprehensive resource of manually curated enhancers and their related information based on low-throughput experimental evidences. Here, we established a comprehensive manually-curated enhancer database for human and mouse, which provides a resource for experimentally supported enhancers, and to

SUBMITTER: Bai X 

PROVIDER: S-EPMC7145688 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature