SIGNOR 2.0, the SIGnaling Network Open Resource 2.0: 2019 update.

ABSTRACT: The SIGnaling Network Open Resource 2.0 (SIGNOR 2.0) is a public repository that stores signaling information as binary causal relationships between biological entities. The captured information is represented graphically as a signed directed graph. Each signaling relationship is associated to an effect (up/down-regulation) and to the mechanism (e.g. binding, phosphorylation, transcriptional activation, etc.) causing the up/down-regulation of the target entity. Since its first release, SIGNOR has undergone a significant content increase and the number of annotated causal interactions have almost doubled. SIGNOR 2.0 now stores almost 23 000 manually-annotated causal relationships between proteins and other biologically relevant entities: chemicals, phenotypes, complexes, etc. We describe he

SUBMITTER: Licata L 

PROVIDER: S-EPMC7145695 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature