Correlation of mucus inflammatory proteins and olfaction in chronic rhinosinusitis.

ABSTRACT:

Background

Chronic rhinosinusitis (CRS) is one of the most common causes of olfactory loss, but the pathophysiology underlying olfactory dysfunction in CRS has not been fully elucidated. Previous studies found correlations between olfactory cleft (OC) inflammatory cytokines/chemokines and olfaction in CRS. The purpose of this study was to evaluate the relationship between OC mucus inflammatory proteins and olfaction in a multi-institutional cohort.

Methods

Adults with CRS were prospectively recruited. Demographics, comorbidities, olfactory assessment (Sniffin' Sticks), computed tomography (CT), and OC mucus for protein analysis were collected. Statistical analysis was performed to determine associations between olfactory function, OC mucus protein concentrations, and CT opac

SUBMITTER: Soler ZM 

PROVIDER: S-EPMC7145735 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature