Metabolic alterations in immune cells associate with progression to type 1 diabetes.

ABSTRACT:

Aims/hypothesis

Previous metabolomics studies suggest that type 1 diabetes is preceded by specific metabolic disturbances. The aim of this study was to investigate whether distinct metabolic patterns occur in peripheral blood mononuclear cells (PBMCs) of children who later develop pancreatic beta cell autoimmunity or overt type 1 diabetes.

Methods

In a longitudinal cohort setting, PBMC metabolomic analysis was applied in children who (1) progressed to type 1 diabetes (PT1D, n = 34), (2) seroconverted to ≥1 islet autoantibody without progressing to type 1 diabetes (P1Ab, n = 27) or (3) remained autoantibody negative during follow-up (CTRL, n = 10).

Results

During the first year of life, levels of most lipids and polar metabolites were lower in the PT1D and P1Ab groups

SUBMITTER: Sen P 

PROVIDER: S-EPMC7145788 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature