Childhood type 1 diabetes: an environment-wide association study across England.

ABSTRACT:

Aims/hypothesis

Type 1 diabetes is an autoimmune disease affecting ~400,000 people across the UK. It is likely that environmental factors trigger the disease process in genetically susceptible individuals. We assessed the associations between a wide range of environmental factors and childhood type 1 diabetes incidence in England, using an agnostic, ecological environment-wide association study (EnWAS) approach, to generate hypotheses about environmental triggers.

Methods

We undertook analyses at the local authority district (LAD) level using a national hospital episode statistics-based incident type 1 diabetes dataset comprising 13,948 individuals with diabetes aged 0-9 years over the period April 2000 to March 2011. We compiled LAD level estimates for a range of potential

SUBMITTER: Sheehan A 

PROVIDER: S-EPMC7145790 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature