Preparation, and Assessment of Antidermatophyte Activity of Miconazole-Urea Water-Soluble Film.

ABSTRACT: Cutaneous mycoses, particularly tinea pedis caused by Trichophyton rubrum, are commonly known infections in humans. They are still considered as a major public health problem worldwide affecting the quality of life due to prolonged period of treatment and development of drug resistance, which leads to recurrence of infections. The objective of our study was to assess the effectiveness of miconazole in the presence and absence of urea, as a penetration enhancer, against T. rubrum and to formulate both of them in a water-soluble film to be applied topically for the purpose of treating tinea pedis caused by this fungus. Drug combination revealed synergism where miconazole minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) (0.5 and 1 mg/L) were considerably decli

SUBMITTER: Mady OY 

PROVIDER: S-EPMC7145891 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature