Targeting the DNA Damage Response for the Treatment of High Risk Neuroblastoma.
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ABSTRACT:
SUBMITTER: Southgate HED
PROVIDER: S-EPMC7145987 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Targeting the DNA Damage Response for the Treatment of High Risk Neuroblastoma.
Southgate Harriet E D HED Chen Lindi L Curtin Nicola J NJ Tweddle Deborah A DA
Frontiers in oncology 20200403
Despite intensive multimodal therapy, the survival rate for high risk neuroblastoma (HR-NB) remains <50%. Most cases initially respond to treatment but almost half will subsequently relapse with aggressive treatment resistant disease. Novel treatments exploiting the molecular pathology of NB and/or overcoming resistance to current genotoxic therapies are needed before survival rates can significantly improve. DNA damage response (DDR) defects are frequently observed in HR-NB including allelic de ...[more]
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