Dose, Timing, and Type of Infant Antibiotic Use and the Risk of Childhood Asthma.

ABSTRACT:

Background

Aspects of infant antibiotic exposure and its association with asthma development have been variably explored. We aimed to evaluate comprehensively and simultaneously the impact of dose, timing, and type of infant antibiotic use on the risk of childhood asthma.

Methods

Singleton, term-birth, non-low-birth-weight, and otherwise healthy children enrolled in the Tennessee Medicaid Program were included. Infant antibiotic use and childhood asthma diagnosis were ascertained from prescription fills and healthcare encounter claims. We examined the association using multivariable logistic regression models.

Results

Among 152 622 children, 79% had at least 1 antibiotic prescription fill during infancy. Infant antibiotic use was associated with increased odds of chil

SUBMITTER: Donovan BM 

PROVIDER: S-EPMC7145998 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature