Complement family member CFI polymorphisms and AMD susceptibility from a comprehensive analysis.

ABSTRACT: The complement factor I (CFI) gene polymorphisms have been reported to age-related macular degenerative (AMD) risk, nevertheless, above association is not consistent. We investigated a meta-analysis to evaluate the conclusions between CFI polymorphisms (rs10033900 and rs2285714) and AMD risk. An identification was covered with the PubMed and other databases through February 8, 2020. Odds ratios (OR) and 95% confidence intervals (CI) were used to assess the strength of associations. After a comprehensive search, 11 different articles (12 case-control studies for total AMD and 11 case-control studies about neovascular disease/geographic atrophy in AMD) were retrieved. Individuals carrying C-allele or CC genotype of rs10033900 polymorphism may have a decreased risk to be AMD disease. For exam

SUBMITTER: Yu Q 

PROVIDER: S-EPMC7146047 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature