Alliin, an Allium sativum Nutraceutical, ReducesMetaflammation Markers in DIO Mice.

ABSTRACT: Obesity generates a chronic low-grade inflammatory state which promotes oxidativestress and triggers comorbidities. Alliin is the main organosulfur compound in garlic and has beenshown to induce a decrease in the expression of proinflammatory cytokines; its systemic effect onmetabolic parameters and adipose tissue is not yet known, however. After nine weeks of HFD andwith obesity established in C57BL/6 mice, we observed that a daily treatment with alliin for 3.5weeks (15 mg/kg) did not affect body weight, but significantly improved insulin sensitivity andglucose tolerance, both evaluated through a blood glucose monitoring system. Once alliin treatmentwas completed, serum, adipose tissue, and organs of interest related to metabolism were removedfor further analysis. We observed that alliin

SUBMITTER: Sanchez-Sanchez MA 

PROVIDER: S-EPMC7146142 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature