Comparative Bioavailability of Different Coenzyme Q10 Formulations in Healthy Elderly Individuals.

ABSTRACT: Coenzyme Q10 (CoQ10) plays a central role in mitochondrial oxidative phosphorylation. Several studies have shown the beneficial effects of dietary CoQ10 supplementation, particularly in relation to cardiovascular health. CoQ10 biosynthesis decreases in the elderly, and consequently, the beneficial effects of dietary supplementation in this population are of greater significance. However, most pharmacokinetic studies have been conducted on younger populations. The aim of this study was to investigate the single-dose bioavailability of different formulations of CoQ10 in a healthy geriatric population. A randomized, three-period, crossover bioavailability study was conducted on 21 healthy older adults (aged 65-74). The treatment was a single dose with a one-week washout period. Three differen

SUBMITTER: Pravst I 

PROVIDER: S-EPMC7146408 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature