Recyclable SERS-Based Immunoassay Guided by Photocatalytic Performance of Fe₃O₄@TiO₂@Au Nanocomposites.

ABSTRACT: A novel recyclable surface-enhanced Raman scattering (SERS)-based immunoassay was demonstrated and exhibited extremely high sensitivity toward prostate specific antigen (PSA). The immunoassay, which possessed a sandwich structure, was constructed of multifunctional Fe₃O₄@TiO₂@Au nanocomposites as immune probe and Ag-coated sandpaper as immune substrate. First, by adjusting the density of outside Au seeds on Fe₃O₄@TiO₂ core-shell nanoparticles (NPs), the structure-dependent SERS and photocatalytic performance of the samples was explored by monitoring and degradating 4-mercaptobenzonic acid (4MBA). Afterwards, the SERS enhancement capability of Ag-coated sandpaper with different meshes was investigated, and a limit of detectio

SUBMITTER: Du Y 

PROVIDER: S-EPMC7146594 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature