A cancer stem cell-like phenotype is associated with miR-10b expression in aggressive squamous cell carcinomas.

ABSTRACT:

Background

Cutaneous squamous cell carcinomas (cSCC) are the primary cause of premature deaths in patients suffering from the rare skin-fragility disorder recessive dystrophic epidermolysis bullosa (RDEB), which is in marked contrast to the rarely metastasizing nature of these carcinomas in the general population. This remarkable difference is attributed to the frequent development of chronic wounds caused by impaired skin integrity. However, the specific molecular and cellular changes to malignancy, and whether there are common players in different types of aggressive cSCCs, remain relatively undefined.

Methods

MiRNA expression profiling was performed across various cell types isolated from skin and cSCCs. Microarray results were confirmed by qPCR and by an optimized in sit

SUBMITTER: Wimmer M 

PROVIDER: S-EPMC7146875 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature