Identification of key genes and pathways associated with feed efficiency of native chickens based on transcriptome data via bioinformatics analysis.

ABSTRACT:

Background

Improving feed efficiency is one of the important breeding targets for poultry industry. The aim of current study was to investigate the breast muscle transcriptome data of native chickens divergent for feed efficiency. Residual feed intake (RFI) value was calculated for 1008 closely related chickens. The 5 most efficient (LRFI) and 5 least efficient (HRFI) birds were selected for further analysis. Transcriptomic data were generated from breast muscle collected post-slaughter.

Results

The differently expressed genes (DEGs) analysis showed that 24 and 325 known genes were significantly up- and down-regulated in LRFI birds. An enrichment analysis of DEGs showed that the genes and pathways related to inflammatory response and immune response were up-regulated in HRFI

SUBMITTER: Yang L 

PROVIDER: S-EPMC7146967 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature