Gray-matter structure in long-term abstinent methamphetamine users.

ABSTRACT:

Background

Previous studies of brain structure in methamphetamine users have yielded inconsistent findings, possibly reflecting small sample size and inconsistencies in duration of methamphetamine abstinence as well as sampling and analyses methods. Here we report on a relatively large sample of abstinent methamphetamine users at various stages of long-term abstinence.

Methods

Chronic methamphetamine users (n = 99), abstinent from the drug ranging from 12 to 621 days, and healthy controls (n = 86) received T1-weighted structural magnetic resonance imaging brain scans. Subcortical and cortical gray-matter volumes and cortical thickness were measured and the effects of group, duration of abstinence, duration of methamphetamine use and onset age of methamphetamine use were inve

SUBMITTER: Nie L 

PROVIDER: S-EPMC7146984 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature