MHC associations of ankylosing spondylitis in East Asians are complex and involve non-HLA-B27 HLA contributions.

ABSTRACT:

Background

The association of HLA-B*27 with AS is amongst the strongest of any known association of a common variant with any human disease. Nonetheless, there is strong evidence indicating that other HLA-B alleles are involved in the disease. European ethnicity studies have demonstrated risk associations with HLA-B*40 and multiple other HLA-B, HLA-A, and HLA class II alleles, and demonstrated that in that ethnic group, the amino acid sequence at position 97 in HLA-B is the key determinant of HLA associations with AS. A recent study in Korean AS cases and controls additionally identified association at HLA-C*15:02. In the current study, we examined the MHC associations of AS in an expanded East Asian cohort.

Methods

A total of 1637 Chinese, Taiwanese, and Korean AS cases mee

SUBMITTER: Wang G 

PROVIDER: S-EPMC7146985 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature