Multi-differentiation potential is necessary for optimal tenogenesis of tendon stem cells.

ABSTRACT:

Background

Tendon injury is a significant clinical problem due to poor healing and a high reinjury rate; successful treatment is limited by our poor understanding of endogenous tendon stem cells. Recent evidence suggests that adult stem cells are phenotypically diverse, even when comparing stem cells isolated from the same tissue from the same individual, and may in fact exist on a spectrum of proliferation and differentiation capacities. Additionally, the relationships between and clinical relevance of this phenotypic variation are poorly understood. In particular, tenogenic capacity has not been studied in comparison to tenogenic differentiation and cell proliferation. Toward this end, we performed a comprehensive assessment of cell proliferation and differentiation capacity towa

SUBMITTER: Rajpar I 

PROVIDER: S-EPMC7146987 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature