Heat shock protein 60 (HSP60) modulates adiponectin signaling by stabilizing adiponectin receptor.

ABSTRACT: Adiponectin, an adipokine produced and secreted by adipocytes, is involved in regulating the development and progression of insulin resistance, diabetes, and diabetic complications. Heat shock protein 60 (HSP60) is a molecular chaperone, most commonly presenting in mitochondria and participating in the maintenance of protein homeostasis. Accumulating studies have demonstrated that the elevated circulating HSP60 and the decreased intracellular HSP60 are closely associated with diabetic complications such as diabetic cardiomyopathy. However, the underlying mechanism remains poorly understood. In the present study, we reported that HSP60 interacted directly with adiponectin receptors. Its abundance was positively associated with adiponectin action. Furthermore, HSP60 depletion markedly mitiga

SUBMITTER: Zhang D 

PROVIDER: S-EPMC7147001 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature