Investigation of sequence features of hinge-bending regions in proteins with domain movements using kernel logistic regression.

ABSTRACT:

Background

Hinge-bending movements in proteins comprising two or more domains form a large class of functional movements. Hinge-bending regions demarcate protein domains and collectively control the domain movement. Consequently, the ability to recognise sequence features of hinge-bending regions and to be able to predict them from sequence alone would benefit various areas of protein research. For example, an understanding of how the sequence features of these regions relate to dynamic properties in multi-domain proteins would aid in the rational design of linkers in therapeutic fusion proteins.

Results

The DynDom database of protein domain movements comprises sequences annotated to indicate whether the amino acid residue is located within a hinge-bending region or within a

SUBMITTER: Veevers R 

PROVIDER: S-EPMC7147021 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature