Copy number variation in human genomes from three major ethno-linguistic groups in Africa.

ABSTRACT:

Background

Copy number variation is an important class of genomic variation that has been reported in 75% of the human genome. However, it is underreported in African populations. Copy number variants (CNVs) could have important impacts on disease susceptibility and environmental adaptation. To describe CNVs and their possible impacts in Africans, we sequenced genomes of 232 individuals from three major African ethno-linguistic groups: (1) Niger Congo A from Guinea and Côte d'Ivoire, (2) Niger Congo B from Uganda and the Democratic Republic of Congo and (3) Nilo-Saharans from Uganda. We used GenomeSTRiP and cn.MOPS to identify copy number variant regions (CNVRs).

Results

We detected 7608 CNVRs, of which 2172 were only deletions, 2384 were only insertions and 3052 had both. W

SUBMITTER: Nyangiri OA 

PROVIDER: S-EPMC7147055 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature