Fission and fusion machineries converge at ER contact sites to regulate mitochondrial morphology.

ABSTRACT: The steady-state morphology of the mitochondrial network is maintained by a balance of constitutive fission and fusion reactions. Disruption of this steady-state morphology results in either a fragmented or elongated network, both of which are associated with altered metabolic states and disease. How the processes of fission and fusion are balanced by the cell is unclear. Here we show that mitochondrial fission and fusion are spatially coordinated at ER membrane contact sites (MCSs). Multiple measures indicate that the mitochondrial fusion machinery, Mitofusins, accumulate at ER MCSs where fusion occurs. Furthermore, fission and fusion machineries colocalize to form hotspots for membrane dynamics at ER MCSs that can persist through sequential events. Because these hotspots can undergo fiss

SUBMITTER: Abrisch RG 

PROVIDER: S-EPMC7147108 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature