Efficacy and Safety of Probiotics in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Irritable bowel syndrome is a functional gastrointestinal disease. Evidence has suggested that probiotics may benefit IBS symptoms. However, clinical trials remain conflicting.

Aims

To implement a systematic review and meta-analysis of clinical trials regarding the efficacy and safety of probiotics for IBS patients.

Methods

We searched for relevant trials in Medline(1966 to Jan 2019), Embase(1974 to Jan 2019), the Cochrane Central Register of Controlled Trials(up to Jan 2019), the ClinicalTrials.gov trials register(up to Jan 2019), and Chinese Biomedical Literature Database(1978 to Jan 2019). Risk ratio (RR) and a 95% confidence interval (CI) were calculated for dichotomous outcomes. Standardized mean difference (SMD) and 95% CI were calculated for continuo

SUBMITTER: Li B 

PROVIDER: S-EPMC7147251 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature