Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study.

ABSTRACT:

Background

Human infections with zoonotic coronaviruses (CoVs), including severe acute respiratory syndrome (SARS)-CoV and Middle East respiratory syndrome (MERS)-CoV, have raised great public health concern globally. Here, we report a novel bat-origin CoV causing severe and fatal pneumonia in humans.

Methods

We collected clinical data and bronchoalveolar lavage (BAL) specimens from five patients with severe pneumonia from Wuhan Jinyintan Hospital, Hubei province, China. Nucleic acids of the BAL were extracted and subjected to next-generation sequencing. Virus isolation was carried out, and maximum-likelihood phylogenetic trees were constructed.

Results

Five patients hospitalized from December 18 to December 29, 2019 presented with fever, cough, and dyspnea accompanie

SUBMITTER: Ren LL 

PROVIDER: S-EPMC7147275 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature