Assessing the impact of arsenic metabolism efficiency on DNA methylation using Mendelian randomization.

ABSTRACT:

Background

Arsenic exposure affects >100 million people globally and increases risk for chronic diseases. One possible toxicity mechanism is epigenetic modification. Previous epigenome-wide association studies (EWAS) have identified associations between arsenic exposure and CpG-specific DNA methylation. To provide additional evidence that observed associations represent causal relationships, we examine the association between genetic determinants of arsenic metabolism efficiency (percent dimethylarsinic acid, DMA%, in urine) and DNA methylation among individuals from the Health Effects of Arsenic Longitudinal Study (n = 379) and Bangladesh Vitamin E and Selenium Trial (n = 393).

Methods

We used multivariate linear models to assess the association of methylation at 221 arseni

SUBMITTER: DiGiovanni A 

PROVIDER: S-EPMC7147391 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature