Relationship between BRSK1 rs12611091 variant and age at natural menopause based on physical activity.

ABSTRACT:

Objectives

The rs12611091 variant in the BR serine/threonine kinase 1 gene is one of the variants previously associated with age at natural menopause. So far, this variant has not been replicated in Taiwanese women. The purpose of this study was to determine the association between rs12611091 and age at natural menopause based on physical activity.

Methods

A total of 1,758 women were eligible for analysis whose information about menopause was collected from the Taiwan Biobank. Multiple linear regression analysis was used for analysis.

Results

The mean age (standard deviation) at natural menopause was 50.82 (3.59) years. Of the eligible participants, 56.94% were rs12611091 CC carriers, 36.69% were TC carriers, and 6.37% were TT carriers. Compared to CC carriers, TC and

SUBMITTER: Su CL 

PROVIDER: S-EPMC7147414 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature