T-Cell-Derived miRNA-214 Mediates Perivascular Fibrosis in Hypertension.

ABSTRACT:

Rationale

Despite increasing understanding of the prognostic importance of vascular stiffening linked to perivascular fibrosis in hypertension, the molecular and cellular regulation of this process is poorly understood.

Objectives

To study the functional role of microRNA-214 (miR-214) in the induction of perivascular fibrosis and endothelial dysfunction driving vascular stiffening.

Methods and results

Out of 381 miRs screened in the perivascular tissues in response to Ang II (angiotensin II)-mediated hypertension, miR-214 showed the highest induction (8-fold, P=0.0001). MiR-214 induction was pronounced in perivascular and circulating T cells, but not in perivascular adipose tissue adipocytes. Global deletion of miR-214^-/- prevented Ang II-

SUBMITTER: Nosalski R 

PROVIDER: S-EPMC7147427 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature