Molecular docking analysis of alkaloid compounds with beta-catenin towards the treatment of colon cancer.

ABSTRACT: It is known that beta-catenin is associated with fibromatosis, sarcoma and mesenchymal tumor. Therefore, it is of interest to design an effective inhibtitor to the target protein beta-catenin. In this study, we report the molecular docking analysis of alkaloid compounds (aristolochicacid, cryptopleurine, demecolcine, fagaronine and thalicarpine) with beta-catenin for further consideration towards the design and development of potential inhintors for the treatmnet of colon cancer.

SUBMITTER: Ponnulakshmi R 

PROVIDER: S-EPMC7147492 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature