NCOR1 Orchestrates Transcriptional Landscapes and Effector Functions of CD4⁺ T Cells.

ABSTRACT: The differentiation of naïve CD4⁺ T cells into T helper (Th) subsets is key for a functional immune response and has to be tightly controlled by transcriptional and epigenetic processes. However, the function of cofactors that connect gene-specific transcription factors with repressive chromatin-modifying enzymes in Th cells is yet unknown. Here we demonstrate an essential role for nuclear receptor corepressor 1 (NCOR1) in regulating naïve CD4⁺ T cell and Th1/Th17 effector transcriptomes. Moreover, NCOR1 binds to a conserved cis-regulatory element within the Ifng locus and controls the extent of IFNγ expression in Th1 cells. Further, NCOR1 controls the survival of activated CD4⁺ T cells and Th1 cells in vitro, while Th17 cell survival w

SUBMITTER: Hainberger D 

PROVIDER: S-EPMC7147518 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature