Prediagnosis aspirin use, DNA methylation, and mortality after breast cancer: A population-based study.

ABSTRACT:

Background

The authors hypothesized that epigenetic changes may help to clarify the underlying biologic mechanism linking aspirin use to breast cancer prognosis. To the authors' knowledge, this is the first epidemiologic study to examine whether global methylation and/or tumor promoter methylation of breast cancer-related genes interact with aspirin use to impact mortality after breast cancer.

Methods

Prediagnosis aspirin use was assessed through in-person interviews within a population-based cohort of 1508 women diagnosed with a first primary breast cancer in 1996 and 1997. Global methylation in peripheral blood was assessed by long interspersed elements-1 (LINE-1) and the luminometric methylation assay. Promoter methylation of 13 breast cancer-related genes was measured in

SUBMITTER: Wang T 

PROVIDER: S-EPMC7147530 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature