No Evidence for Widespread Positive Selection Signatures in Common Risk Alleles Associated with Schizophrenia.

ABSTRACT: Schizophrenia poses an evolutionary-genetic paradox as it exhibits strongly negative fitness effects (early mortality and decreased fecundity), yet it persists at a prevalence of approximately 1% worldwide. Evidence from several studies have suggested that schizophrenia is evolved and maintained in part as a maladaptive byproduct of recent positive selection and adaptive evolution in human beings. However, inconsistent results have been also proposed, challenging the recent positive selection theory to explain the high population frequency of schizophrenia-associated alleles. Here, we used public domain data to locate signatures of positive selection based on genetic diversity, derived allele frequency, differentiation between populations, and long haplotypes at schizophrenia-associated si

SUBMITTER: Yao Y 

PROVIDER: S-EPMC7147583 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature