Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae.

ABSTRACT: In several areas of the central nervous system, neurons are regionally organized into groups or layers that carry out specific activities. In this form of patterning, neurons of distinct types localize their cell bodies to just one or a few of the layers within a structure. However, little is known about whether diverse neuron types within a lamina share molecular features that coordinate their organization. To begin to identify such candidates, we used the laminated murine retina to screen 92 lacZ reporter lines available through the Knockout Mouse Project. Thirty-two of these displayed reporter expression in restricted subsets of inner retina neurons. We then identified the spatiotemporal expression patterns of these genes at key developmental stages. This uncovered several that were hea

SUBMITTER: Jiang D 

PROVIDER: S-EPMC7147688 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature