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S100A9-targeted tobacco mosaic virus nanoparticles exhibit high specificity toward atherosclerotic lesions in ApoE-/- mice.


ABSTRACT: We integrate a biocompatible plant virus-based nanotechnology (tobacco mosaic virus, TMV) with S100A9-targeting peptides for its application in imaging and diagnosis of atherosclerosis. S100A9-targeted TMV nanoparticles exhibit remarkable specificity to S100A9 and targeting of atherosclerosis lesions in ApoE-/- mice.

SUBMITTER: Park J 

PROVIDER: S-EPMC7147689 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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S100A9-targeted tobacco mosaic virus nanoparticles exhibit high specificity toward atherosclerotic lesions in ApoE<sup>-/-</sup> mice.

Park Jooneon J   Gao Huiyun H   Wang Yunmei Y   Hu He H   Simon Daniel I DI   Steinmetz Nicole F NF  

Journal of materials chemistry. B 20190213 11


We integrate a biocompatible plant virus-based nanotechnology (tobacco mosaic virus, TMV) with S100A9-targeting peptides for its application in imaging and diagnosis of atherosclerosis. S100A9-targeted TMV nanoparticles exhibit remarkable specificity to S100A9 and targeting of atherosclerosis lesions in ApoE<sup>-/-</sup> mice. ...[more]

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