Boron doped silver-copper alloy nanoparticle targeting intracellular S. aureus in bone cells.

ABSTRACT: OBJECTIVES:Alloyed metallic nanoparticles of silver and copper are effective against intracellular infection. However, systemic toxicity may arise due to the non-specific delivery of the nanoparticles. In addressing the issue, this study deals with the targeting of silver-copper-boron (ACB) nanoparticles to infected osteoblasts, which could decrease systemic toxicity and form the basis of targeting specific markers expressed in bone infections. METHODS:ACB nanoparticles were synthesized and conjugated to the Cadherin-11 antibody (OBAb). The effect of targeting nanoparticles against extracellular and intracellular S. aureus was determined by enumeration of bacterial growth. The binding of the targeting nanoparticles to infected osteoblasts as well as the visualization of live/dead bacteria

SUBMITTER: Abdulrehman T 

PROVIDER: S-EPMC7147743 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature