Final analysis of the international observational S-Collate study of peginterferon alfa-2a in patients with chronic hepatitis B.

ABSTRACT:

Background and aims

Sustained off-treatment immune control is achievable in a proportion of patients with chronic hepatitis B treated with peginterferon alfa-2a. We evaluated on-treatment predictors of hepatitis B surface antigen (HBsAg) clearance 3 years after peginterferon alfa-2a treatment and determined the incidence of hepatocellular carcinoma.

Methods

A prospective, international, multicenter, observational study in patients with chronic hepatitis B who have been prescribed peginterferon alfa-2a (40KD) in a real-world setting. The primary endpoint was HBsAg clearance after 3 years' follow-up.

Results

The modified intention-to-treat population comprised 844 hepatitis B e antigen (HBeAg)-positive patients (540 [64%] completed 3 years' follow-up), and 872 HBeAg-neg

SUBMITTER: Marcellin P 

PROVIDER: S-EPMC7147799 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature