A novel postsynaptic signal pathway of sympathetic neural regulation of murine colonic motility.

ABSTRACT: Transcriptome data revealed α1 adrenoceptors (ARs) expression in platelet-derived growth factor receptor α⁺ cells (PDGFRα⁺ cells) in murine colonic musculature. The role of PDGFRα⁺ cells in sympathetic neural regulation of murine colonic motility was investigated. Norepinephrine (NE), via α1A ARs, activated a small conductance Ca²⁺ -activated K⁺ (SK) conductance, evoked outward currents and hyperpolarized PDGFRα⁺ cells (the α1A AR-SK channel signal pathway). α1 AR agonists increased intracellular Ca²⁺ transients in PDGFRα⁺ cells and inhibited spontaneous phasic contractions (SPCs) of colonic muscle through activation of a SK conductance. Sympathetic nerve stimulation inhibited both contractions of dista

SUBMITTER: Kurahashi M 

PROVIDER: S-EPMC7147814 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature