Changing predictors of statin initiation in US women over two decades.

ABSTRACT: PURPOSE:To describe changing roles of predictors of statin initiation before and after incident coronary heart disease, and before and after publication of National Cholesterol Education Program Adult Treatment Panel-III (ATP-III) guidelines in a cohort of US women. METHODS:We identified 34 382 women enrolled into the Women's Health Study from 1993 to 1995 and followed up until 2012. Proportions of previous nonusers initiating statins were described over time. We used multivariable linear regression models to estimate adjusted initiation proportion differences (IPDs) for initiation overall, separately before and after incident coronary heart disease, and separately for ATP-II and ATP-III time periods. RESULTS:Key predictors of initiation overall were self-reported total cholesterol, and pr

SUBMITTER: Kinsey TL 

PROVIDER: S-EPMC7147936 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature