Fine Particulate Matter Exposure and Cerebrospinal Fluid Markers of Vascular Injury.

ABSTRACT:

Background

Cerebrovascular diseases play an important role in dementia. Air pollution is associated with cardiovascular disease, with growing links to neurodegeneration. Prior studies demonstrate associations between fine particulate matter (PM2.5) and biomarkers of endothelial injury in the blood; however, no studies have evaluated these biomarkers in cerebrospinal fluid (CSF).

Objective

We evaluate associations between short-term and long-term PM2.5 exposure with CSF vascular cell adhesion molecule-1 (VCAM-1) and e-selectin in cognitively normal and mild cognitive impairment (MCI)/Alzheimer's disease (AD) individuals.

Methods

We collected CSF from 133 community volunteers at VA Puget Sound between 2001-2012. We assigned short-term PM2.5 from central monitors and lon

SUBMITTER: Shaffer RM 

PROVIDER: S-EPMC7147945 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature