Microbial burden and inflammasome activation in amniotic fluid of patients with preterm prelabor rupture of membranes.

ABSTRACT: Background Intra-amniotic inflammation, which is associated with adverse pregnancy outcomes, can occur in the presence or absence of detectable microorganisms, and involves activation of the inflammasome. Intra-amniotic inflammasome activation has been reported in clinical chorioamnionitis at term and preterm labor with intact membranes, but it has not yet been investigated in women with preterm prelabor rupture of membranes (preterm PROM) in the presence/absence of detectable microorganisms. The aim of this study was to determine whether, among women with preterm PROM, there is an association between detectable microorganisms in amniotic fluid and intra-amniotic inflammation, and whether intra-amniotic inflammasome activation correlates with microbial burden. Methods Amniotic fluids from

SUBMITTER: Theis KR 

PROVIDER: S-EPMC7147952 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature