Genomic and clinical characterization of pulmonary-only metastatic prostate cancer: A unique molecular subtype.

ABSTRACT:

Background

Isolated pulmonary involvement is uncommon in metastatic hormone-sensitive prostate cancer (mHSPC). To characterize outcomes and molecular alterations of this unique patient subset, we conducted a retrospective review of patients with hormone-naïve prostate cancer presenting with lung-only metastases.

Methods

This was a retrospective single-institution study. Medical records of 25 patients presenting with pulmonary-only metastases before receiving androgen deprivation therapy (ADT) were analyzed. Germline and/or somatic genomic results, where available (n = 16), were documented. Tumor tissue was analyzed using clinical-grade next-generation DNA sequencing assays. Clinical endpoints included complete prostate-specific antigen (PSA) response to ADT (<0.1 ng/mL), med

SUBMITTER: Shenderov E 

PROVIDER: S-EPMC7147974 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature