Polygenic Risk Score-Derived Subcortical Connectivity Mediates Attention-Deficit/Hyperactivity Disorder Diagnosis.

ABSTRACT:

Background

Attention-deficit/hyperactivity disorder (ADHD) has substantial heritability, and a recent large-scale investigation has identified common genome-wide significant loci associated with increased risk for ADHD. Along the same lines, many studies using noninvasive neuroimaging have identified differences in brain functional connectivity in children with ADHD. We attempted to bridge these studies to identify differences in functional connectivity associated with common genetic risk for ADHD using polygenic risk score (PRS).

Methods

We computed ADHD PRSs for all participants in our sample (N = 315, children 7-13 years of age, 196 with ADHD and 119 unaffected comparison children) using ADHD data from the Psychiatric Genomics Consortium as a discovery set. Magnetic reson

SUBMITTER: Hermosillo RJM 

PROVIDER: S-EPMC7147985 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature