Quantitative Benefit-Risk Models Used for Rotavirus Vaccination: A Systematic Review.

ABSTRACT:

Background

Although rotavirus vaccines have proven to prevent the risk of rotavirus gastroenteritis (RVGE) in children under 5 years old, they are also associated with an increased transient risk of intussusception (IS). Several quantitative benefit-risk models (qBRm) are performed to measure this balance in hospitalizations and deaths prevented versus the ones induced.

Method

In this study, our objective was to provide a complete overview of qBRm used for rotavirus vaccination. We systematically searched 3 medical literature databases to identify relevant articles, in English, that were published between 2006 and 2019.

Results

Of the 276 publications screened, 14 studies using qBRm for rotavirus vaccination were retained, based on preselected criteria. Four were perf

SUBMITTER: Arlegui H 

PROVIDER: S-EPMC7148003 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature