Novel tau filament fold in corticobasal degeneration.

ABSTRACT: Corticobasal degeneration (CBD) is a neurodegenerative tauopathy-a class of disorders in which the tau protein forms insoluble inclusions in the brain-that is characterized by motor and cognitive disturbances^1-3. The H1 haplotype of MAPT (the tau gene) is present in cases of CBD at a higher frequency than in controls^4,5, and genome-wide association studies have identified additional risk factors⁶. By histology, astrocytic plaques are diagnostic of CBD^7,8; by SDS-PAGE, so too are detergent-insoluble, 37 kDa fragments of tau⁹. Like progressive supranuclear palsy, globular glial tauopathy and argyrophilic grain disease¹⁰, CBD is characterized by abundant filamentous tau inclusions that are made of isoforms with four microtubule

SUBMITTER: Zhang W 

PROVIDER: S-EPMC7148158 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature